Merkel Cell Carcinoma Histology
Definition general first described as an entity in 1972 as trabecular carcinoma of skin arch dermatol 1972105107.
Merkel cell carcinoma histology. It has also been called toker tumour cutaneous neuroendocrine carcinoma trabecular cell carcinoma and primary small cell carcinoma of the skin. Renamed in 1980 patients with mcc are at higher risk to develop neoplasms of hepatobiliary tract salivary glands non hodgkin lymphoma commonly coexists with chronic. Histology of merkel cell carcinoma. Arise from the epidermis very rarely in situ.
Merkel cell carcinoma mcc is a rare type of skin cancer. Cutaneous ewing sarcoma sorted out with immunostains. Rate rises and is currently about 06100000year. It may be very aggressive and often metastasises to other parts of the body.
Merkel cell carcinoma primarily affects the sun exposed skin of elderly males and preferentially the head and neck region. Mcc tends to grow quickly and can be hard to treat if it spreads beyond the skin. The tumour is centered in the dermis with frequent involvement of the overlying epidermis figures 1 2 and may invade the subcutaneous fat. Merkel cell carcinoma is a rare but highly malignant tumor of the skin with high rates of metastasis and poor survival.
Clinical differential diagnoses include basal cell carcinoma cyst amelanotic melanoma lymphoma and atypical. It is also known as cutaneous apudoma primary neuroendocrine carcinoma of the skin primary small cell carcinoma of the skin and trabecular carcinoma of the skin. Merkel cell carcinoma lymph node metastases is difficult to diagnose with routine stains. Merkel cell carcinoma mcc is also called neuroendocrine carcinoma of the skin.
The tumour forms sheets nests and rarely ribbons. Merkel cell carcinoma is a neuroendocrine carcinoma composed of densely blue cells. Use of ihc stains are advised. It starts when cells in the skin called merkel cells start to grow out of control.
Its a type of skin cancer that occurs when cells in the skin known as merkel cells grow uncontrollably. Merkel cell carcinoma of the skin is a rare form of skin cancer. The classic pattern of ck20 expression is dot like and paranuclear. How rare is it.
Merkel cell carcinoma is aggressive and associated with high mortality.