Merkel Cell Carcinoma Skin Histology
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Factors involved in the development of mcc include the merkel cell polyomavirus a weakened immune system and exposure to ultraviolet radiation.
Merkel cell carcinoma skin histology. Merkel cell carcinoma is aggressive and associated with high mortality. The cell of origin remains debatable but the immunohistochemical profile and morphology resemble native merkel cells in the skin. Ultraviolet radiation immunosuppression and the merkel cell polyomavirus mcpyv are thought to be causative factors. A rare skin cancer merkel cell carcinoma mcc is a rare aggressive form of skin cancer with a high risk for returning recurring and spreading metastasizing often within two to three years after initial diagnosis.
Most merkel cell carcinomas appear on the face head or neck but they can develop anywhere on your body even on areas not exposed to sunlight. Its a type of skin cancer that occurs when cells in the skin known as merkel cells grow uncontrollably. Merkel cell carcinoma mcc is a rare type of skin cancer. When to see a doctor.
The classic pattern of ck20 expression is dot like and paranuclear. Merkel cell carcinoma usually arises on the head neck and e. Merkel cell carcinoma primarily affects the sun exposed skin of elderly males and preferentially the head and neck region. Skin merkel cell carcinoma of the skin merkelcell 4001.
Merkel cell carcinoma is an aggressive tumour that usually arises on chronically sun exposed skin of the elderly. This protocol can be utilized for a variety of procedures and tumor types for clinical care purposes. It is also known as cutaneous apudoma primary neuroendocrine carcinoma of the skin primary small cell carcinoma of the skin and trabecular carcinoma of the skin. The nodule may be skin colored or may appear in shades of red blue or purple.
The first sign of merkel cell carcinoma is usually a fast growing painless nodule tumor on your skin. For accreditation purposes only the definitive primary cancer resection specimen is required to have the core and. Merkel cell carcinoma is a rare and aggressive skin cancer occurring in about 3 people per 1000000 members of the population. It starts when cells in the skin called merkel cells start to grow out of control.
Mcc is a small round blue cell tumor composed of monomorphous cells with scant almost indiscernible cytoplasm and round to oval or polygonal hyperchromatic nuclei with dispersed chromatin and inconspicuous nucleoli nuclei often appear to be arranged back to back and may show moulding mitoses and apoptotic bodies are frequent.
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